2025

Single-Walled Carbon Nanotubes as a Support for Palladium-Catalyzed Aquachemical Cross-Coupling Reactions
T. Kitanosono*, S. Shiramizu, Y. Yamashita, S. Kobayashi*
em>Org. Lett., ASAP (2025). DOI: 10.1021/acs.orglett.5c04162

Pd-catalysed flow Tsuji–Trost allylation of phenols: continuous-flow, extraction-free synthesis of esmolol via allylation, epoxidation, and aminolysis
K. Kobayashi*, M. Yamashita, T. Kimura, Y. Kon, T. Nakashima, S. Onozawa*, S. Kobayashi*
Org. Chem. Front., Advance Article (2025). DOI: 10.1039/D5QO01336D

Pharmaceuticals Made with Hydrogen: A Sustainable and Efficient Approach Using Flow Synthesis
S. Kobayashi*, H. Ishitani*
Chem. Eur. J., Early View (2025). DOI: 10.1002/chem.202502889

La(SPh)3 as a Superior Multifunctional Catalyst for Photoinduced Alkylation Reactions of Active Methylene Compounds with Nonactivated Alkenes
T. Hisada, Y. Sato, Y. Yamashita*, S. Kobayashi*
Chem. Lett., Accepted Manuscript (2025). DOI: 10.1093/chemle/upaf174

Noncovalent Immobilization of Chiral Lewis Acids on Single-Walled Carbon Nanotubes as a Tool for Synthetic Organic Aquachemistry
T. Kitanosono*, S. Tanaka, D. Zhang, T. Hisada, Y. Yamashita, S. Kobayashi*
Chem. Sci., Accepted Manuscript (2025). DOI: 10.1039/D5SC05390K

Organobase-catalyzed Phosphonylation of Alcohols
D. Mrdović, Y. Saito, S. Kobayashi*
Bull. Chem. Soc. Jpn., Accepted Manuscript (2025). DOI: 10.1093/bulcsj/uoaf078

Visible-Light-Driven Catalytic Alkylation of Reactive Alkyl Nitriles with Nonactivated Alkenes Using an Amine as a Hydrogen Atom Transfer Catalyst
Y. Sato, T. Hisada, Y. Yamashita*, S. Kobayashi*
Org. Lett., 27, 4701-4705 (2025). DOI: 10.1021/acs.orglett.5c01072

Triarylmethyl Cations as Photocatalysts for Radical-Mediated Cycloaddition Reactions
T. Hisada, K. Maeda, Y. Yamashita*, S. Kobayashi*
Org. Lett., 27, 4366-4371 (2025). DOI: 10.1021/acs.orglett.5c01103

Platinum-Catalyzed Regioselective Dehydrogenative Homocoupling of Dimethyl Phthalate for the Direct Synthesis of Sym-BPTT
S. Ishikawa, K. Iseki, H. Ishitani*, S. Kobayashi*
Sus. Circ. Now, 2, a25574354 (2025). DOI: 10.1055/a-2557-4354

Enhanced Photocatalytic Alkylation using Mg(SPh)2: The Role of Lewis Acidity in Catalyst Activity
Y. Yamashita*, T. Hisada, Y. Sato, S. Kobayashi*
Helv. Chim. Acta, 108, e202400207 (2025). DOI: 10.1002/hlca.202400207

Efficient low-temperature depolymerization of polycarbonate catalyzed by lanthanum β-diketonate complexes
Y. Kinbara, H. Ishitani*, S. Kobayashi*
Green Chem., 27, 7544-7550 (2025). DOI: 10.1039/D5GC00829H

Photoinduced Catalytic Alkylation of Active Methine Compounds with Nonactivated Alkenes Using Yttrium Triflate as a Lewis Acid Catalyst
Y. Yamashita*, R. Enokijima, Y. Ogasawara, T. Hisada, S. Kobayashi*
Adv. Synth. Catal., 367, e202401568 (2025). DOI: 10.1002/adsc.202401568

Mg(SPh)2 as a Catalyst for Efficient Photocatalytic Alkylation Reactions of Active Methylene Compounds with Nonactivated Alkenes
Y. Yamashita*, T. Hisada, Y. Sato, S. Kobayashi*
Adv. Synth. Catal., 367, e202401554 (2025). DOI: 10.1002/adsc.202401554

Continuous-flow synthesis of carboxylic acids from alcohols via platinum and silicon dioxide-catalyzed hydrogen peroxide oxidation
Y. Kon, T. Nakashima, Y. Makino, S. Onozawa, H. Miyamura, S. Kobayashi*, K. Sato*
Org. Biomol. Chem., 23, 2125-2132 (2025). DOI: 10.1039/D4OB01668H
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2024

Development of Continuous-Flow Reactions for the Synthesis of Anti-Alzheimer Drug Memantine
M. Iwata, Y. Furiya, H. Ishitani*, S. Kobayashi*
Chem. Eur. J., , Accepted Article (2024). DOI: 10.1002/chem.202403562

Continuous-flow synthesis of cyclic carbonates with polymer-supported imidazolium-based ionic liquid (Im-PSIL) catalysts
Z. Yu, H. Ishitani*, S. Kobayashi*
Green Chem., , Advance Article (2024). DOI: 10.1039/D4GC04499A

Structure-Directed Quaternary Ammonium Hydroxide Resins: High-Performance Heterogeneous Base Catalysts for Continuous-Flow Carbon–Carbon Bond-Forming Reactions
H. Ishitani*, Y. Furiya, A. Ide, S. Kobayashi*
J. Org. Chem., 89, 14081-14089 (2024). DOI: 10.1021/acs.joc.4c01506

Solid-Acid Catalyzed Continuous-Flow Aminolysis of Epoxides
K. Nishizawa, Y. Saito, S. Kobayashi*
Chem. Eur. J., Early View e202403094 (2024). DOI: 10.1002/chem.202403094

Sequential-Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation
H. Ishitani*, H. Sogo, Y. Furiya, S. Kobayashi*
Chem. Eur. J., Early View (2024). DOI: 10.1002/chem.202402128

TEMPO-Catalyzed Continuous-flow Aerobic Oxidations of Alcohols on Silica
K. Takizawa*, T. Ishihara, S. Tani, Y. Hamada, K. Masuda, S. Onozawa*, K. Sato, S. Kobayashi*
ChemCatChem, Accepted Article (2024). DOI: 1002/cctc.202401152

Vigorously Stirred La2O3 Suspensions for Michael Additions in Water
T. Hisada, R. Osada, T. Kitanosono*, Y. Yamashita, S. Kobayashi*
Chem. Commun., 60, 9994-9996 (2024). DOI: 10.1039/D4CC02343A

Small-Molecule-Based Strategy for Mitigating Deactivation of Chiral Lewis Acid Catalysis
F. Lu, T. Kitanosono*, Y. Yamashita, S. Kobayashi*
J. Am. Chem. Soc., 146, 22918-22922 (2024). DOI: 10.1021/jacs.4c07449

Direct Aromatic Nitrosation Using 2-Methoxyethyl Nitrite as a NO Cation Source
A. Hashidoko, T. Kitanosono*, Y. Yamashita, S. Kobayashi*
Org. Lett., 26, 5517-5521. DOI: 10.1021/acs.orglett.4c01856

Continuous-flow Directed C–H Amidation Reactions Using Immobilized Cp*Rh(III) Catalysts
Y. Saito, T. Konno, S. Kobayashi*
Green Chem., 26 8680-8684 (2024). DOI: 10.1039/D4GC01747A

Selective Hydrogenation of Quinizarins to Leuco-quinizarins and Their Direct Derivatization Using Flow-Batch-Separator Unified Reactors under Continuous-Flow Conditions
H. Miyamura*, A. Sharma, M. Takata, R. Kajiyama, S. Kobayashi, Y. Kon
ACS Catal., 14, 10317-10323 (2024). DOI: 10.1021/acscatal.4c02955

Catalytic Activation of Bis(2,2,2-trifluoroethyl) phosphite with Hf(IV) for the Synthesis of Mixed Dialkyl Phosphites
D. Mrdović, Y. Saito, S. Kobayashi*
Adv. Synth. Catal., Early View. DOI: 10.1002/adsc.202400497

Flow Chemistry and Continuous Processing: More Mainstream than Ever!
K. P. Cole*, J. N. Jaworski, C. O. Kappe, S. Kobayashi, A. R. Maguire, A. O’Kearney-McMullan, J. A. Pesti
Org. Process Res. Dev., 28, 1269-1271 (2024). DOI: 10.1021/acs.oprd.3c00483

Nanoscale and chiral metal–organic frameworks for asymmetric reactions in water: bridging Lewis acid catalysis and biological systems
W. Srimontree, T. Kitanosono*, Y. Yamashita, S. Kobayashi*
Chem. Sci., 15, 9120-9126 (2024). DOI: 10.1039/D4SC01343C

Efficient Radical-mediated Intermolecular α-Alkylation Reactions of Carbonyl Compounds with Nonactivated Alkenes
Y. Yamashita, S. Kobayashi*
Chem. Asian J., 19, e202400319 (2024). DOI: 10.1002/asia.202400319

Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane–Palladium Catalysts under Continuous-Flow Conditions
T. Senzaki, Y. Saito, S. Kobayashi*
Org. Lett., 26, 3772-3777 (2024). DOI: 10.1021/acs.orglett.4c00876

A Highly Efficient Catalytic Method for the Synthesis of Phosphite Diesters
Y. Saito, S. M. Cho, L. A. Danieli, A. Matsunaga, S. Kobayashi*
Chem. Sci., 15, 8190-8196 (2024). DOI: 10.1039/D4SC01401D

Development of Catalytic Enantioselective Mannich Reactions Using Esters
Y. Yamashita*, S. Fushimi, T. Banik, T. Kimura, S. Kobayashi*
Org. Lett., 26, 1579-1583 (2024). DOI: 10.1021/acs.orglett.3c04326

Continuous Synthesis of Homoallylic Ketones via Ketal–Claisen Rearrangement using Solid-Acid Catalysts
K. Kobayashi*, C. Negoro, J. Takaishi, K. Masuda*, S. Kobayashi*
Org. Chem. Front., 11, 1990-1995 (2024). DOI: 10.1039/D3QO01889J

Continuous-Flow Enantioselective Hydrogenative Enyne Cyclization with Chiral Heterogeneous Rh Catalysts
Y. Saito, Y. Sato, S. Kobayashi*
ACS Catal., 14 2202-2206 (2024). DOI: 10.1021/acscatal.3c05868

Enantioselective Acyl-Transfer/Protonation Reactions with Newly Designed Chiral Thiourea-Iminophosphorane Catalysts
J. Kong, C. Lacroix, C. Bournaud, Y. Yamashita, S. Kobayashi*, G. Vo-Tanh*
Adv. Synth. Catal., 366, 1101-1106 (2024). DOI: 10.1002/adsc.202301394

Water vs. Organic Solvents: Water-Controlled Divergent Reactivity of 2-Substituted Indoles
A. Hashidoko, T. Kitanosono*, Y. Yamashita, S. Kobayashi*
Chem. Asian J., 19, e202301045 (2024). DOI: 10.1002/asia.202301045

Continuous-Flow Asymmetric Hydrogenation for the Synthesis of an (S)-Metolachlor Intermediate Using Catalysts Immobilized on a Core/Shell-Type Support
T. Kuremoto, T. Yasukawa, S. Kobayashi*
Adv. Synth. Catal., 366, 757-761 (2024). DOI: 10.1002/adsc.202301251